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An USB isolator helps remove ground loops and lowers electromagnetic interference (EMI) between the computer as well as connected product.1x GND 3V3 (P2 with two pins 2.54mm) connector can be employed to energy externally the WCH CH569 MCU (it is usually recommended to remove the P4/SHUNT in that scenario It isn't obligatory given that the 3V3 LDO